Micromanaging tolerance
نویسندگان
چکیده
منابع مشابه
Micromanaging Glucose Tolerance and Diabetes
MicroRNAs (miRNAs) are endogenous non-coding RNAs that have significant roles in biological processes such as glucose homoeostasis. MiRNAs fine-tune target genes expression via sequence-specific binding of their seed sequence to the untranslated region of mRNAs and degrade target mRNAs. MicroRNAs in islet β-cells regulate β-cell differentiation, proliferation, insulin transcription and glucose-...
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Normal somatic cells have a limited capacity for division in culture and eventually enter a state of terminal growth arrest termed replicative senescence [1]. Cells that fail to undergo senescence divide indefinitely and develop chromosomal aberrations resulting in neoplastic transformation. Senescence is believed to be a tumor suppressor mechanism that ensures that cells permanently exit the c...
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Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipu...
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Two parallel and concordant activities characterize cell cycle progression. One is associated with preparation for and execution of DNA replication followed by mitosis (" cell cycle "). Cyclins are the motors of the cell cycle, as they activate the respective CDKs and thereby drive the cell through the sequential phases of the cycle. Their antagonists are CKis, which inhibit the CDKs stalling t...
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The kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2012
ISSN: 1945-3477
DOI: 10.1038/scibx.2012.1226